金沙集团wwW3354CC2018年度春季学期学术系列讲座之十
题目：CRISPR-Cas Mediated Cleavage of Invading Nucleic Acids
讲座人：王艳丽博士
研究员
中国科学院生物物理研究所
中国科学院核酸生物学重点实验室
时间：2018年5月25日（星期五），14:00-15:30
地点：我院邓祐才报告厅
主持人：高宁教授
摘要：
Bacteria and archaea are protected against invading nucleic acids from phages and plasmids because of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas (CRISPR associated proteins) systems, which are RNA-guided prokaryotic adaptive immune system. CRISPR-Cas systems are found in nearly half of all bacteria studied so far, as well as in the majority of archaea. However, throughout evolution, this host defense system has not resulted in the eradication of phages, suggesting that phages have evolved counter strategies to thrive within bacteria despite these mechanisms. Thus, both bacterial CRISPR system and phage anti-CRISPR system are part of a continuing evolutionary battle between bacterial host and their bacteriophage invaders. We provided significant insights into the molecular mechanism for how CRISPR-Cas systems defend against the invading nucleic acids from phages and how phages counteract the CRISPR-Cas systems by anti-CRIPR proteins.
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