金沙集团wwW3354CC2017年度春季学期学术系列讲座之五
题目：Illuminating Biochemical Activity Architecture of the Cell
讲座人：Jin Zhang，Ph.D.
Professor, 
Department of Pharmacology, 
Department of Bioengineering and Department of Chemistry and Biochemistry, 
The university of California, San Diego
Adjunct Professor, 
Department of Pharmacology & Molecular Sciences, 
The Johns Hopkins University School of Medicine
时间：2017年3月31日，13:00 - 14:30
地点：我院邓祐才报告厅
主持人：李毓龙
摘要：
The complexity and specificity of many forms of signal transduction are widely suspected to require spatiotemporal regulation of signaling molecules, such as protein kinases, phosphatases and second messengers. These signaling activities are often compartmentalized in nanoscale domains that define the biochemical architecture of the cell. Despite advances in molecular sensors and optical imaging, direct interrogation of any minute activity domains at the molecular length scale remains a challenge. In this talk, I will focus on cAMP and Ca2+ regulated signaling activities and present studies where we combined genetically encoded fluorescent biosensors, superresolution imaging, targeted biochemical perturbations and mathematic modeling to probe the biochemical activity architecture of the cell. 
欢迎各位老师同学积极参加！