个人介绍:

陈雪梅教授1988年获得北京大学生物学学士学位，1995年获得美国康奈尔大学生物化学博士学位，随后在加州理工学院进行博士后研究。她于1999年在罗格斯大学瓦克斯曼研究所担任助理教授，于2005年晋升为副教授，并获得罗格斯大学董事会学术卓越研究奖。她于2005年转至加州大学河滨分校，任副教授，2009年晋升为正教授，2013年晋升为讲席教授。自2023年2月起，任金沙集团wwW3354CC讲席教授、院长。2006年获美国植物生物学家协会颁发的查尔斯·阿尔伯特·舒尔奖，2011年当选为AAAS研究员，2012年至2018年任HHMI-GBMF研究员。2013年当选为美国国家科学院院士。2018年获得了南加州华裔科学家和工程师协会的成就奖。2023年获美国植物生物学家协会颁发的Martin Gibbs Medal. 2024年获得求是基金会的杰出科学家奖。她的研究方向是花的发育、植物小RNA和RNA修饰。

教育经历:

1984-1988 学士，北京大学
1989-1995 博士，美国康奈尔大学

工作经历:

2023-　　院长，金沙集团wwW3354CC
2023-　　特聘教授，北京大学
2013-2023 特聘教授，加州大学河滨分校
2009-2013 教授，加州大学河滨分校
2005-2009 副教授，加州大学河滨分校
1999-2005 助理教授，美国罗格斯大学 （新泽西州立大学）
1995-1998 博士后，美国加州理工学院

社会服务工作:

Keystone symposia Scientific Advisory Board， 2022-2025
Scientific Advisory Board, Max Planck Institute, Tubingen, 2023-2026
Gibbs Medal Committee, American Association of Plant Biologists, 2025

荣誉奖励:

杂志任职:

Editorial Board member of Developmental Cell, 12/2024 - present
Senior editor, The Plant Cell, 04/2020 – present
Consulting Editor of PLOS Genetics, January 2016 - present
Editorial Board member of National Science Review 2015 – present
Editorial Board member of Molecular Plant, December 2014 – present
Editorial Board member of Science in China, 2014 - present

      早期研究植物花形态建成的基因调控机制，发现与RNA代谢相关的蛋白参与花器官分化。进而发现其中某些蛋白参与小RNA 代谢与功能。之后主要研究小RNA的生物合成， 降解，及作用机制。
目前的主要研究方向之一为小RNA的细胞间运输机制及作为信号分子调控植物响应温度变化的机制。第二个主要研究方向为RNA的非典型加帽修饰， 比如NAD， FAD， dpCoA 帽子的加入，去除机制及分子功能。第三个研究方向为叶绿体发育， 基因表达， 及RNA 修饰。

Runlai Hang*,Hao Li, Runyu Wang, Hao Hu, Meng Chen, Chenjiang You* and Xuemei Chen*. (2024). HOT3/eIF5B1 confers Kozak motif-dependent translational control of photosynthesis-associated nuclear genes for chloroplast biogenesis. Nature Comm. accepted.

Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, and Xuemei Chen*. (2024). Toll/interleukin-1 receptor (TIR) domain-containing proteins exhibit deNAMing activity towards NAD-capped RNAs. Nature Comm. 15: 2261. 10.1038/s41467-024-46499-y

Qing Sang, Lusheng Fan, Tianxiang Liu, YongjianQiu, Juan Du, Beixin Mo, Meng Chen*, and Xuemei Chen*. (2023). MicroRNA156 conditions auxin sensitivity to enable growth plasticity in response to environmental changes in Arabidopsis. Nature Comm. 14, 1449.

Yuan Wang, Brandon H. Le, Jianqiang Wang, Chenjiang You, Yonghui Zhao, Mary Galli, Ye Xu, Andrea Gallavotti, Thomas Eulgem, Beixin Mo*, and Xuemei Chen*. (2022). A novel factor that recruits and excludes Pol IV-mediated DNA methylation in a site-specific manner. Science Advances 8, DOI: 10.1126/sciadv.adc9454.

Lusheng Fan, Cui Zhang, Yong Zhang, Ethan Stewart, Jakub Jez, Keiji Nakajima, and Xuemei Chen*. (2022). Microtubules promote the non-cell autonomous action of microRNAs by inhibiting their cytoplasmic loading onto ARGONAUTE1 in Arabidopsis. Dev. Cell. 57, 995-1008.

Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203.

Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.

Yuan Wang, Shaofang Li, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia and Xuemei Chen*. (2019). NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. PNAS 116, 12094-12102

Zhenxia Su, Lihua Zhao, Yuanyuan Zhao, Shaofang Li, So Youn Won, Hanyang Cai, Lulu Wang, Zhenfang Li, Yuan Qin*, and Xuemei Chen*. (2017). The THO complex non-cell autonomously represses female germline specification through the TAS3-ARF3 module. Current Biology 27, 1597–1609.

Yu Yu, Lijuan Ji, Brandon Le, Jixian Zhai, Jiayi Chen, Elizabeth Luscher, Lei Gao, Chunyan Liu, Xiaofeng Cao, Beixin Mo, Jinbiao Ma, Blake C. Meyers, and Xuemei Chen*. (2017). ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology 15(2): e2001272.

Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhel, Liwen Jiang, and Xuemei Chen*. (2013). microRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.

Yuanyuan Zhao, Yu Yu, Jixian Zhai, Vanitharani Ramachandran, Thanh Theresa Dinh, Blake C. Meyers, Beixin Mo*, and Xuemei Chen*. (2012). The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Current Biology 22, 689-694.

Vanitharani Ramachandran and Xuemei Chen*. (2008). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490-1492.

Junjie Li, Zhiyong Yang, Bin Yu, Jun Liu, and Xuemei Chen*. (2005). Methylation protects miRNAs and siRNAs from a 3’ end uridylation activity in Arabidopsis. Current Biology 15, 1501-1507.

Bin Yu, Zhiyong Yang, Junjie Li, Svetlana Minakhina, Maocheng Yang, Richard W. Padgett, Ruth Steward, and Xuemei Chen*. (2005). Methylation as a crucial step in plant microRNA biogenesis. Science 307, 932-935.

Xuemei Chen*. (2004). A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025.